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Synapsin: Antiaging, Inflammation, Cognitive Health Booster

Synapsin Nasal Spray Interview with James LaValle

Inflammation and Chronic Illness

“Inflammation is a feature of every chronic illness in addition to traumatic brain injuries; people who have PTSD, people who are losing memory, Parkinson’s patients, obese patients. Literally, people who have gained weight, microglial cell activation is thought to be the center of why people lose their fat thermostat and their metabolism’s ability to burn fat.
Bottom line if you have neuroinflammation, not just your brain is aging at an accelerated rate—your whole body will age at an accelerated rate.”

– Synapsin Nasal Spray Interview with James LaValle (podcast content used with permission from Healthy Choices XM/ Ray Solano podcast/radio interview with Dr. Jim LaValle about rG3 (Synapsin)

Invention of Synapsin


Synapsin was invented by renowned author, pharmacist and functional medicine speaker Jim LaValle, RPh, CCN, ND, and is commonly used in combination with methylcobalamin in formulations to support neuronal function and cognition.

Synapsin is an innovative blend of ginsenoside Rg3 and nicotinamide riboside. It is an ingredient designed to be used in dietary supplement formulations for the support of neurological and cognitive health.

The idea for Synapsin (RG3 Nicotinamide Riboside Methylcobalamin Nasal Spray) Started in a clinic in Ohio that had a large Autism Spectrum Disorder section. Why are their brains on fire?

Immune cells are in the brain that get turned on called microglial cells. Microglial cells get turned on that crank out inflammatory compounds that damage your brain over time.

Dr. LaValle says he stumbled upon the idea of Synapsin because of the Autism Spectrum population and then realized brain inflammation is a universal problem. It can help a broad range of individuals.

Synapsin nasal spray formulation is a combination of Gensenoside (RG3) nicotinamide riboside and methyl b12 (methylcobalamin). The combination has positive effects to reduce brain inflammation. The combination of all three ingredients together–there is a story.

More Information on RG3 (Synapsin®)


LaValle says a professor from Beijing first introduced the gensenoside RG3 to him. He set it aside and didn’t do much with it but then later started doing research on glial cells and what affects them. He started searching getting all these results about gensenoside and how it reduces inflammation. He remembered that the professor had tried to tell him this.

RG3 and formulating it, there were initial problems dissolving it and it’s expensive to make. We want to deliver it right to the brain.  You can get by with less and get it in the nasal mucosa and get it to cross into the brain. A lot of people utilize it. You need something to turn the inflammation off and nutrients to turn on the mitochondria (powerhouses of the neurons) on so they can be repaired.  

Your brain can continue to bud new neurons and prune those neurons as you are aging. You don’t just lose neurons. If your brain is healthy and your inflammation is under control, you can bud new neurons and restore cognitive capacity.

 Some people believe neurons can’t be regenerated. But with the right nutrients, your body does regenerate new neurons.

It’s one thing to turn off the fire it’s another thing to rebuild.

NR is interesting, it’s a household name in the dietary supplement industry. It can trigger NAD levels to increase. NAD levels help with carrying energy and stimulating energy production in the cells of your brain. NAD stimulates mitochondria, the powerhouses of the cells. Your challenge as you are aging is to keep the mitochondria healthy and churning out energy so that you can feel vibrant.  NAD is essential in generating mitochondrial potential. NR stimulates NAD activity in every cell of your body. It generates energy and repairs tissue. When mitochondria die, your cells die. Aging is considered a mitochondrial disorder. When cells can’t function appropriately you can’t send messages to creatre normal body function. Energy, blood sugar regulation, immune surveillance.

Gensenoside is longer acting. NR is shorter acting and works more spontaneously. The combination of the 2 allows the patient to benefit short term. 

People report that in the first couple of days, their mental acuity picked up. They were able to hold intense thoughts throughout the day instead of experiencing their typical executive type burnout at the halfway point in the day.

The brain is aging. We are dealing with environmental insults, genetics, diet, lifestyle.

Alzheimer’s Disease, Traumatic Brain Injuries — there are not a lot of pharmaceutical solutions to these problems. Conventional medicine saves millions of lives every day. However, it has fallen short for management for chronic conditions. Memory should be considered a chronic condition. Stress is a chronic condition; so many people are burned out by age 40 because of the amount of stress in their lives, long work hours, poor nutrition, lack of sleep. punishing bodies, drinking alcohol.

Then…you are wondering why at age 45 you forget where your car keys are, you don’t have recall you used to have. More people should reach out to recapture their brain health before the diseases occur.

We should work on having a resilient brain so if you do have trauma, then your brain can healthy to heal.

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