Why is a compounding pharmacy necessary for topical losartan?
Losartan is only commercially available in tablet form, there is not an ophthalmic form available. Commercial tablets may not be used to compound a sterile product. Only experienced, high quality compounding pharmacies should compound losartan topical for the eye.
“Oral losartan does not penetrate the cornea and, therefore, has no effect on the fibrosis response to injury or corneal wound healing .”
Source: Cleveland Clinic
Potential Applications of Topical Losartan (Ocular)
Dr. Wilson’s article in the Journal of Ocular Pharmacology and Therapeutics includes conditions that should be examined, including:
Corneal scarring fibrosis due to:
Lacerations
Refractive surgery complications, such as PRK late haze or complicated LASIK or SMILE
Viral infections, such as herpes simplex keratitis and herpes zoster ophthalmicus
Bacterial, fungal or acanthamoeba keratitis
Epidemic keratoconjunctivitis scars
Chemical burns
Endothelial corneal graft displacement
TGF beta-induced corneal dystrophies
Conjunctival fibrotic diseases, such as trachoma and Stevens-Johnson syndrome
Glaucoma surgery complications, such as conjunctival bleb scarring and shunt encapsulation
Hypertrophic skin scars on eyelids and in the periocular area
More info on Losartan: Topical Losartan (Opthalmic) Eye Drops
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