Low Dose Naltrexone (LDN)
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LDN Overview
Which patients may benefit from LDN therapy?
- Chronic pain
- Hashimoto’s
- Parkinson’s disease
- Arthritis
- Graves’ disease
- Alzheimer’s
- Ulcerative Colitis
- Crohn’s Disease
- Psoriasis
- Eczema
- Neuroinflammation
- Sjogren’s Syndrome
- Inflammation
- Multiple Sclerosis
- Irritable bowel
- Celiac disease
- Autism
- Fibromyalgia
- Lupus
- Traumatic Brain Injury (TBI)
- Cancer
- HIV/Aids
- Lyme Disease
- Weight Loss
- Animals
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Dr. Asher Goldstein
Board Certified Physician Specializing in Pain Management and Opioid Detox
From the Experts
Learn About LDN From an Experienced Physician
Get insight from providers that prescribe Low Dose Naltrexone (LDN) for their patients.
LDN Titration
LDN & Lyme Disease
LDN & CRPS
LDN & Fibromyalgia
LDN Overview
LDN Titration
Titrating the LDN dose is very important for success
LDN Presentation
Low Dose Naltrexone (LDN) Presentation/Pain Management and Immune Dysfunction Diseases
Pain Management & Immune Dysfunction: Disease presentation by Dr. Asher Goldstein.
Low Dose Naltrexone (LDN) Resources
Featured LDN Review Article:
The Use of Low-Dose Naltrexone (LDN) as a Novel Anti-Inflammatory Treatment for Chronic Pain
Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells.
This review covers the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.
Frequently Asked Questions About LDN
What is Low Dose Naltrexone (LDN)?
Low Dose Naltrexone, or LDN, refers to naltrexone used at doses much lower than the standard 50 mg tablet. LDN is commonly prescribed in individualized doses and has been studied for several chronic pain, inflammatory, and other conditions.
What are compounded medications?
There is no single LDN dose that is appropriate for every patient. Published studies commonly use doses within the low-milligram range, often around 1 to 4.5 mg daily, but the prescribed dose may vary based on the patient, condition, response, and prescriber’s clinical judgment. LDN may also be started at a lower dose and gradually adjusted over time.
Why is LDN only Available as a Compounded Medication?
Commercially manufactured naltrexone tablets are generally available in a 50 mg strength, while LDN prescriptions typically require much smaller doses. A compounding pharmacy can prepare the specific strength and dosage form prescribed for an individual patient when a commercially available product does not meet that need.
Can Narcotic Pain Relievers be Used While on LDN?
The answer is No.
The effects of narcotics will be blocked by LDN. If a patient has developed any degree of narcotic dependence, LDN may cause withdrawal symptoms, some of which can be extremely uncomfortable or dangerous.
Careful consideration should be given to those cases before initiating LDN. We have worked with pain management specialists that have weaned patients off of narcotic analgesics while titrating up LDN therapy.
What are the Side Effects of LDN?
LDN is generally reported as well tolerated in published studies, but side effects can occur. Reported effects include vivid dreams or sleep changes, nausea, gastrointestinal discomfort, diarrhea, headache, and dizziness. Side effects and their severity can vary by patient and dose. Patients experiencing persistent or concerning symptoms should contact their prescriber or pharmacist.
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