Why Stimate® Nasal Spray Was Recalled

Ferring Pharmaceuticals, the manufacturer of Stimate® Nasal Spray, issued a retail-level recall after routine testing showed that some vials were out of specification. Certain lots were found to be "superpotent" — containing a higher concentration of desmopressin than intended. The root cause was still under investigation, and supply disruption was expected to continue into mid-to-late 2021.

"Ferring has issued a voluntary retail level recall of Stimate. We are working closely with the U.S. Food & Drug Administration (FDA) on the recall."

— Ferring Pharmaceuticals & CSL Behring

What Is Desmopressin?

Desmopressin is used in people with Hemophilia A and Type 1 Von Willebrand's Disease (VWD) to regulate bleeding that may be caused by trauma or surgery. VWD is a clotting disorder in which Von Willebrand Factor (VWF) — a protein in the blood that helps with clotting — is too low. Type 1 VWD is the mildest and most common form. Patients with VWD may also have lower-than-normal levels of clotting protein factor VIII. Hemophilia Type A is characterized by normal VWF levels but low or absent levels of factor VIII.

Desmopressin acetate also stops bleeding in patients experiencing spontaneous or trauma-induced injuries such as hemarthroses, intramuscular hematomas, and mucosal bleeding.