Home arrow Low Dose Naltrexone (LDN)

What is LDN

Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells.

Conditions treated

Chronic pain, Hashimoto’s, Parkinson’s disease, Arthritis, Graves’ disease, Alzheimer’s, Ulcerative Colitis, Crohn’s Disease, Psoriasis, Eczema, Neuroinflammation, Sjogren’s Syndrome, Inflammation, Multiple Sclerosis,
Irritable bowel, Celiac disease, Autism, Fibromyalgia, Lupus, Traumatic Brain Injury (TBI), Cancer, HIV/Aids, Lyme Disease, Weight Loss, Animals

Titrating the LDN dose is very important for success

We provide titration kits to help each patient find the perfect dose that works for them

  • Check Icon Ultra Low Dose Naltrexone (ULDN)1 to 100 microgram (mcg) dose
  • Check Icon Very Low Dose Naltrexone (VLDN)100 to 500 mcg dose
  • Check Icon Low Dose Naltrexone (LDN)Typically 0.5 to 4.5mg dose
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How to get started

Find the right LDN Dosage Form for your specific needs & preferences.

Low Dose Naltrexone (LDN) Titration Kit Using Oral Capsules

Doses for LDN are very individualized, and one dose does not fit all. Because of this, we offer titration kits so patients can gradually work their way to their ideal dose. We have helped many patients to not “overshoot” their dose by starting too high.

LDN Low Dose Naltrexone Titration Kit Using Oral Liquid

The titration kit enables a patient to start their low dose naltrexone therapy and slowly ease into the dose that is appropriate for them. This compound was created for patients who cannot swallow capsules.

Compounded Low Dose Naltrexone (LDN)

Low Dose Naltrexone (LDN) is a novel approach to decrease release of inflammatory substances, reduce nerve cell inflammation and autoimmune mediators.

Low Dose Naltrexone Oral Liquid

Naltrexone in a liquid may be prescribed for patients who may have a hard time swallowing oral capsules or for patients who may have to adjust their dose quite often or who have not yet found their perfect dose.

Very Low Dose Naltrexone (VLDN) in Capsules

This dose of naltrexone is typically in the range of 100mcg to 500mcg and is often prescribed for patients who are on a low controlled dose of an opioid and working with their physician to come off of opioid therapy and transition to low dose naltrexone as an alternative option to opioids

Topical Low Dose Naltrexone (LDN) in a Cream

Some medical conditions require the topical administration of naltrexone alone or in combination with other active pharmaceutical ingredients (API’s). Town & Country Compounding can compounding Low Dose Naltrexone (LDN) into elegant topical cream bases that are non-irritating for the patient. If there are special ingredients that must be avoided due to an allergy, we can take care of that as well.

Topical Low Dose Naltrexone in a Vaginal Cream or Gel

Some conditions require LDN to be administered by itself or in combination with another drug in a vaginal cream or gel.

Ultra-Low Dose Naltrexone (ULDN) in Oral Liquid

This dose of naltrexone is typically in the range of 2mcg to 100mcg and is often prescribed for patients who are currently taking opioids. In this ultra-low dose, patients have reported increased pain relief without blocking the effect of their opioid medication. Many patients are then hopefully able to work closely with their physician to lower their opioid dose. Patients have also reported a decreased need to increase their opioid dose while taking ULDN.Oral Liquid form for patients with difficulty swallowing capsules.

Low Dose Naltrexone (LDN) FAQs

It’s important to ask questions when researching medications, especially when it comes to pain relief. Many individuals looking for alternatives to addictive opioids have found Low Dose Naltrexone (LDN) can be the solution.

What is Low Dose Naltrexone (LDN)?

Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells.

What is the Appropriate Dose of LDN?

It really does take an experienced pharmacist and experienced physician working together to get to the sweet spot with dosing for the specific condition. It’s not as simple as starting a titration at 1.5mg and then going all the way to 4.5. We have seen situations where the patient gets full pain relief at 3mg and must stop, but if they keep going, they will lose the results.

Can Narcotic Pain Relievers be Used While on LDN?

A Common question that our expert pharmacists get asked is Can narcotic pain relievers be used while on LDN? 

The answer is No. 

The effects of narcotics will be blocked by LDN. If a patient has developed any degree of narcotic dependence, LDN may cause withdrawal symptoms, some of which can be extremely uncomfortable or dangerous. 

Careful consideration should be given to those cases before initiating LDN. We have worked with pain management specialists that have weaned patients off of narcotic analgesics while titrating up LDN therapy. 

Why is LDN only Available as a Compounded Medication?

Naltrexone is commercially available only in a 50 mg tablet. However, low-dose naltrexone (LDN) therapy is usually prescribed as 0.5mg-4.5 mg per day, adjusted to the correct dose depending on the patient’s response.

Compounding pharmacies use naltrexone powder from FDA-approved facilities to formulate individualized dosing based on a prescription order. Prescribers should ensure that the compounding facility they choose is an accredited compounding lab.

What are the Side Effects of LDN?

Side effects of LDN are few and have not been commonly reported.

Most common side effects have been:

• VIVID dreams are common, usually only lasting a few days; if these become bothersome for the patients, the time of dose could be adjusted to the am

• Stomach cramps/diarrhea – rare

• Increased thyroid sensitivity; medication may need adjustment

• Flu-like symptoms; if longer than 24 hours, the dose may be cut in half until symptoms resolve

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At Town & Country Compounding, we do our best to work with the patient and the practitioner to offer alternative options.

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