What is Ketamine?
Ketamine is a class III scheduled controlled substance best known for its use in surgery as a general anesthetic. Ketamine is also used in various other areas of medicine, such as in patients with pain, anxiety, PTSD, treatment-resistant depression, suicidal ideations, bipolar disorder, and more.
Ketamine is commercially available only in very limited forms. Ketamine can be compounded into various dosage forms customized to the concentration or dose you need only by a qualified compounding pharmacy.
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Precautions
Ketamine may impair mental and/or physical ability. Use care when driving or operating machinery. Do not take it with alcohol, sleep aids, tranquilizers, or other central nervous system depressants.
If you miss your regular dose of ketamine, take it when you remember but do not take a double dose to make up for the missed one. Do not exceed or change the prescribed dose.
Consult your healthcare practitioner if any prescription or over-the-counter medications are currently (or will be) used.
Contact your practitioner immediately if you experience serious side effects within 24 hours after you take ketamine.
Possible side effects
Dream-like feelings, floating sensations, hallucinations, double vision or blurred vision, jerky muscle movements, dizziness, drowsiness, nausea, vomiting, loss of appetite, or sleep problems.
Possible drug Interactions
Before using this product, tell your doctor or pharmacist about all the products you use. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.
Storage
Ketamine should be stored out of the reach of children,
in a cool place away from sunlight. Ketamine troches
are sensitive to heat and will melt at high temperatures.
Store this medication at 68°F to 77°F and avoid heat,
moisture, and light.
Ketamine can be compounded into different dosage forms
- Nasal Spray
- Troches
- Mini-Troches
- Rapid Dissolve Tablets (RDTs)
- Oral Solution
- Oral Capsules
Please contact our pharmacy if you have any questions or concerns about your medication.
Call or text 201-447-2020 info@tccompound.com
Dosing varies depending on dosage form, indication, and patient-specific response.
Sterile & Non-Sterile Ketamine Forms
Ketamine Infusion IV Bags
Ketamine Vials (Injection)
Ketamine Nasal Spray
Compounded ketamine nasal spray is a well-known dosage form and contains a different isomer than the commercial ketamine nasal spray, therefore has different advantages. Compounded ketamine does not require office administration like the commercial product.
Rapid onset: 5-10 mins
Ketamine Capsules
A good option for those sensitive to the taste of ketamine in all other dosage forms. The absorption and onset are slower than troches.
Variable onset: 30 mins-hours
Ketamine Rapid Dissolve Tablets (RDTs)
These dissolve faster than larger troches. One tablet may be cut into four pieces for flexible dosing, allowing easy titration. Directions: Dissolve tablet(s) in the mouth (on the tongue).
Ketamine Sublingual/Oral Solution
It can be used orally or sublingually, depending on the concentration and dose desired.
The advantage of using a solution is that it has a quick onset, and it is also easy for the doctor to make dosage adjustments without the patient needing a new prescription compounded. The disadvantages are that a liquid is less convenient and has a shorter expiration date than other dosage forms.
Ketamine Troches (Lozenges)
Troches are small lozenges that can be placed and dissolved between the cheek and gum (buccally) or under the tongue (sublingually) to deliver medication. Troches should not be chewed or swallowed. Medication delivered this way is absorbed quicker than taking medication orally. Ketamine is naturally very bitter. Therefore, we add sweeteners and flavors to mask the bitterness. The higher the dose, the harder it is to mask the bitterness.
Rapid onset: 10-15 mins
Ketamine Four-Scored Troches
These troches can be divided in 4’s so the patient can adjust the dose as directed. Directions: Dissolve (¼, ½, ¾, or one) troche under the tongue or between the cheek and gum, as directed.
Ketamine Mini Troches (Lozenges)
Ketamine mini troches are the most commonly prescribed ketamine troches. These are small, dissolve easily and are very convenient.
