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RG3 (Synapsin®) Nasal Spray & Neuroinflammation

T&C Compounding – Experts in the Compounding RG3 (Synapsin®) Nasal Spray

RG3 (Synapsin®) Nasal Spray

Rg3 is one of several triterpene saponins (ginsenosides) found in the plant genus Panax, including Panax ginseng (Asian ginseng) and Panax quinquifolius (American ginseng). Laboratory studies report that Rg3 extracted from Panax ginseng supports neuroprotection, helping to support healthy microglial activity and healthy neuronal function.

  • quells inflammation, gets neurons to bud (and refueled),and gets the mitochondria to calm down the microglia.
  • triggers mitochondrial rejuvenation -mitochondria become fully active and generate energy in the brain
  • helps with sirtuins (SIRT1’s) which are regulators of metabolism.
  • improves receptor activation. Often, when you give supplements or hormones, the results are affected by the receptors and how active they are. 
Ask your doctor for a prescprition for Methylcobalamin (RG3-Synapsin®) Spray

How can we quiet that brain cell activation which leads to inflammation?
According to Dr. James LaValle,  RG3 and Nicotinamide Riboside may help. 

What do we know about inflammation?

Stress causes people to feel scattered and feeling like they can’t think straight. They often wonder what is happening to them.

Neuroinflammation is an inflammation of the central nervous system (CNS). It can lead to neuronal injury and dysfunction.

What can lead to neuroinflammation?

  • Traumatic brain injuries (Concussions, motor vehicle accidents, injury from violence)
  • Autoimmune diseases
  • By-products of diseases- circulating endotoxins
  • Microglial activation- different components to inflammation are led by microglial cells
  • Chronic stress- Chronic stress involves elevated cortisol which can lead to microglial activation via the release of inflammatory cytokines.  In other words, stress often causes chronic inflammation which can lead to neuronal injury or death and therefore changes in behavior. It interferes with all stages of neuronal renewal. 

Possible Causes of Inflammation

Traumatic Brain Injuries, examples 

Dr. James LaValle: Director of the NFL Hall of Fame Center for Excellence for research on traumatic brain injuries.

  • NFL players with concussions (as well as many other sports)
  • Military people such as Navy Seals after being in combat zones
  • Motor Vehicle Accidents
  • Electric Shock
  • Violence Injury


  • Diabetes
  • Parkinson’s
  • Alzheimer’s (Dementia)
  • Autism Spectrum Disorder
  • ADHD
  • Autoimmune Diseases
  • ALS (Lou Gehrig’s Disease)
  • Lyme Disease
  • Mold
  • Stroke /TIA’s

Chronic Stress Situations

  • Executive Burnout
  • Career stress—see an example of racecar drivers
  • Lifestyle stress- money, marriage, kids 
  • Overloaded parents with “jello brain”

Get Educated, Become a Preferred Prescriber

Practitioners, if you would like to see a full presentation on Neuroinflammation and Methylcobalamin (RG3-Synapsin®) Spray, or would like to see if you qualify to be one of our preferred prescribers that we refer, please enter your name and email address & phone number.

Do You Need a Referral to a Methylcobalamin (RG3-Synapsin®) Spray Prescriber?

T&C Compounding works with the most prestigious providers. We work with you and health providers/specialists to formulate the most customized medication regimens to fit your specific needs. Medication is not one-size-fits-all, our compounding specialists use precise compounding techniques & equipment to get you the best solution.


How to properly prepare, prime, and store your T&C Nasal Spray Medication for maximum results.

Expert Pharmacist Grace Kim

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