Topical Metformin and Treating PCOS, Diabetes, Excessive Facial Hair (Hirsutism)
Recent research in treatment advancements
Do you have PCOS, Diabetes, or Excessive Facial Hair?
TOPICAL METFORMIN may be an option for you.
Patients with any of these conditions may be prescribed metformin.
What is Metformin?
Metformin is a drug that is used in women’s health for polycystic ovarian syndrome (PCOS), problems with excessive facial hair (hirsutism) and is also used as a treatment for diabetes. Metformin reduces circulating insulin, which decreases the concentration of free levels of androgens. It is most commonly prescribed as an oral dosage form (tablets or solution).
However, unwanted side effects are often seen with taking metformin orally. Nausea, vomiting, gas, bloating, diarrhea, and loss of appetite and can occur in one out of three patients who take it. These side effects cause many patients to discontinue therapy.
Alternative Dosage Form
Topical metformin in a permeation enhancing base may help eliminate those side effects. It must be made by a compounding pharmacy. Topical metformin allows the drug to be absorbed into the body without having to take it orally.
Topiclick METFORMIN dispenser
Topical metformin in a permeation enhancing base may be an effective treatment for those who cannot tolerate taking metformin orally due to side effects, or for those who cannot take large tablets. It must be obtained from a compounding pharmacy and requires a prescription.
If switching from an oral dose to a topical dose in a permeation enhancing base, it is important to reduce the topical dose. Transdermal metformin is typically dosed at only 5-10% of the normal oral dose, and this significantly reduced actual dose has achieved effects that are clinically comparable. Your doctor can speak with the pharmacists at T&C Compounding for suggestions. Patients should monitor their blood sugar often, especially when changing dosage forms.
In other words, oral administration often leads to gastrointestinal side effects which causes people to stop taking the drug and stops the progress of the treatment for their condition. Transdermal administration may be a way to avoid this and allow the patient to remain on the therapy!
Metformin: Skin Conditions
Metformin is known to improve hyperinsulinemia, therefore it has proven beneficial in hormonal acne and hidradenitis suppurativa, which is a chronic skin condition featuring lumps in places such as the armpits or groin. The skin lesions develop as a result of inflammation and infection of sweat glands. It is also used as a treatment for acanthosis nigricans, which is a condition characterized by hyperpigmentation of the skin.
To read more about metformin in dermatologic conditions, see
An Innovative Option for Hirsutism: Topical Metformin
By Sara Hover
Metformin: Excessive Hair Growth (hirsutism) and PCOS
Related: Hairy Females: Do You Have Unwanted Hair on the Face or Chin? It’s called Hirsutism.
Hirsutism means excessive growth of stiff, pigmented hair (known as “terminal hair”) is often very bothersome for women on the chin, or lip area. The excessive hair growth may be caused by underlying polycystic ovarian syndrome (PCOS) or an unknown cause.
It is well known that metformin reduces circulating androgens, which can decrease the occurrence of excess hair in women, it’s possible that applying metformin topically may inhibit and reduce terminal hair growth.
Studies have shown that hair follicles that are exposed to excessive levels of insulin exhibit a higher growth rate. Conversely, hair follicles maintained in the absence of insulin or at typical levels prematurely entered a catagen-like state.
Metformin is indicated as an off-label treatment for polycystic ovarian syndrome because it reduces circulating insulin, which decreases the concentration of free levels of androgens. A few studies have examined the influence of metformin on hirsutism as the primary end point.
Kelly and Gordon—in a 14 month, randomized, double-blind, placebo-controlled crossover trial—demonstrated a modest reduction in hirsutism at the end of treatment.1
Metformin’s antiandrogenic properties allow it to be an adjunct to conventional management of hirsutism associated with polycystic ovarian syndrome (PCOS).2,3
Town & Country Compounding: Metformin Experts
Topical Metformin Formulas
Metformin HCl 10% Lipoderm® has a BUD Study attached to it so it can have a 180 beyond use date.
We have a 10%(100mg/ml) and 20% (200mg/ml) in an anhydrous permeation enhancing base called PermE8® Anhydrous) will have a 180 day beyond use date.
Others:
Testosterone /Metformin/Lipoderm Base (Permeation Enhancing)
Metformin/Progesterone/Spironolactone in PermE8 (Permeation Enhancing)
Metformin/Spironolactone/Progesterone in a Topical Gel (for topical use on the face or chin)
Interested in Metformin?
Nutritional supplements that may be of interest to patients with hirsutism, diabetes or PCOS
Call or email our expert pharmacists with any questions. You can now order our supplements online!
Diabetes Balance (RF)
Diabetes Balance (RF) is a complete product that addresses blood sugar function and promotes healthy balance and regulation.
$68.80/ 120 Caps
Vitamin B-12 Cyanocobolamin 500 mcg
Vitamin B12 (as cyanocobalamin) tablets supply 500 mcg of vitamin B-12 in each easy-to-swallow tablet.
$12.95/ 100 Tablets
Berberine HCl 500mg
Helps to normalize blood sugar levels and lipid levels when taken daily. Gluten-free, non-GMO and vegan.
$48.00/ 60 Caps
Flax Seed Oil 1000mg
Flax seed oil is nature’s most concentrated source of alpha-linolenic acid (ALA), an essential omega-3 fatty acid. Flax Seed Oil supplement provides ALA, as well as significant amounts of oleic acid and the essential linoleic acid in their natural triglyceride forms. Flax Seed Oil is extracted without the damaging effects of heat, light, and oxygen using a mechanical expeller press. Using this process, the oil never is exposed to temperatures above 96º F, and it retains its natural color and contents of naturally occurring fatty acids, phosphatides, vitamins, minerals, and antioxidants. Organic Flax Seed Oil is available as a liquid or in softgel form.
$17.40/ 100 Caps
Vitamin D3 5000 IU
Even though the human body can manufacture vitamin D, there is evidence that much of the American population suffers from a deficiency of this nutrient. Supplementation with vitamin D is critical to helping maintain healthy bone remodeling.
$19.90/ 100 Softgels
Check out our Facebook Live Video educating patients and providers about the importance of checking Vitamin D levels, especially concerning COVID.
Vitamin D Levels utilizing at-home blood spot kits. Avoid labs & doctor offices.
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T&C Compounding works with the most prestigious providers. We work with patients and health providers/specialists to formulate the most customized medication regimens to fit your specific needs. Medication is not one-size-fits-all, our compounding specialists use precise compounding techniques & equipment to get you the best solution.
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References
1.Kelly, C. J., & Gordon, D. (2002). The effect of metformin on hirsutism in polycystic ovary syndrome. European Journal of Endocrinology, 147(2), 217-221. Retrieved from http://www.eje-online.org/content/147/2/217.long
2.Bubna AK. Metformin – For the dermatologist. Indian J Pharmacol. 2016;48(1):4-10. doi:10.4103/0253-7613.174388
3. Kazerooni T, Dehghan-Kooshkghazi M. Effects of metformin therapy on hyperandrogenism in women with polycystic ovarian syndrome. Gynecol Endocrinol. 2003;17(1):51-56.
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