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Topical Losartan (Ophthalmic) and Corneal Scarring

Topical Losartan Eye Drops are Compounded at Town & Country Compounding​

Potential Applications of Topical Losartan (Ocular)

Dr. Wilson’s article in the Journal of Ocular Pharmacology and Therapeutics includes conditions that should be examined, including:

Corneal scarring fibrosis due to: 

  • Lacerations
  • Refractive surgery complications, such as PRK late haze or complicated LASIK or SMILE
  • Viral infections, such as herpes simplex keratitis and herpes zoster ophthalmicus
  • Bacterial, fungal or acanthamoeba keratitis
  • Epidemic keratoconjunctivitis scars
  • Chemical burns
  • Endothelial corneal graft displacement
  • TGF beta-induced corneal dystrophies
  • Conjunctival fibrotic diseases, such as trachoma and Stevens-Johnson syndrome
  • Glaucoma surgery complications, such as conjunctival bleb scarring and shunt encapsulation
  • Hypertrophic skin scars on eyelids and in the periocular area 

Source : Cleveland Clinic

Topical Losartan: Practical Guidance for Clinical Trials in the Prevention and Treatment of Corneal Scarring Fibrosis and Other Eye Diseases and Disorders https://pubmed.ncbi.nlm.nih.gov/36877777/

Learn more about topical Losartan from pharmacist Viral Jani, PharmD, RPh.

Questions about dosing?

Contact our pharmacists.

Why is a compounding pharmacy necessary for topical losartan?

Losartan is only commercially available in tablet form, there is not an ophthalmic form available. Commercial tablets may not be used to compound a sterile product. Only experienced, high quality compounding pharmacies should compound losartan topical for the eye. 

“Oral losartan does not penetrate the cornea and, therefore, has no effect on the fibrosis response to injury or corneal wound healing .”

Rigorous protocols lead to excellent patient outcomes.

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Our accreditations place us in the top 1% of compounding pharmacies

Accredited Sterile Compounding Pharmacy

Clinical Trial Medications at Town & Country Compounding

To inspire more clinical trials, Dr. Wilson recently published in the Journal of Ocular Pharmacology and Therapeutics a list of ocular conditions that potentially could be treated with topical losartan, along with practical guidelines for using it.

Premium Laboratories for Clinical Trials

We are the highest quality compounding pharmacy for clinical trials.

Town & Country Compounding is a 503A PCAB/ACHC accredited sterile and non-sterile compounding pharmacy lab. We are USP 795 and 797 compliant as well as USP 800 compliant for both USP 795/797 (sterile and non-sterile compounding labs).

Exterior view of Town & Country Compounding Pharmacy building

Our new pharmacy with state-of-the-art compounding laboratories is designed to enhance our capabilities in working with clinical trials. 

Why choose Town & Country Compounding for Clinical Trials?

Other Ophthalmic Compounded Medications at
Town & Country Compounding

Intravitreal Injection Examples

  • Ganciclovir
  • Amikacin
  • Clindamycin
  • Dexamethasone
  • Methotrexate
  • Vancomycin
  • Voriconazole
  • Ceftazidime
  • Amphotericin B
  • tPA

Other Ophthalmic Compounds

  • Brilliant blue 
  • PF Tropicamide 
  • Losartan
  • Betadine syringes (single unit dose)
  • Mitomycin
  • Phenylephrine /tropicamide / ofloxacin /tetracaine / flurbiprofen syringes(P10 eyedrops) or custom combinations
  • Lidocaine /epinephrine / BSS (Shugarcaine) syringes or vials
Call or Text: 201-447-2020