Unlocking the Potential: Sublingual Compounded Tirzepatide & Semaglutide (GLP-1 Medications)

Our accreditations place us in the top 1% of compounding pharmacies

Sublingual GLP-1 Medications: Town & Country Compounding has a new, sublingual compounded tirzepatide and semaglutide option for patients, making dosing comfortable, easy and convenient.

In recent months, the shortages of GLP-1 injections such as Ozempic, Wegovy (semaglutide), Mounjaro, and Zepbound (tirzepatide) has prompted concern among clinicians and patients alike as demand for these medications has soared. 

The recent surge in popularity of GLP-1 receptor agonists has been remarkable. Among these agents, tirzepatide and semaglutide stand out for their potential in glucose control and weight management.

This shortage, listed on the official FDA shortage registry, has prompted a collective call to action within the healthcare community. Town & Country Compounding has emerged as a vital resource, offering innovative services to provide patients with access to essential therapy without interruption.

In the realm of medical innovation, the recent developments surrounding compounded GLP-1 medications present an exciting prospect, especially in the form of sublingual administration. The simplicity and painlessness of the sublingual route may lead to better adherence to therapies.

This leap towards a more user-friendly approach (compared to an injection) signifies a potential game-changer for individuals who have avoided using the most popular injectable form for various reasons. In this blog, we’ll unravel the whys and hows of sublingual compounded tirzepatide and semaglutide — GLP-1 agonists.

Why Compounded Sublingual GLP-1 Medications (Semaglutide and Tirzepatide)?

Prescriptions for sublingual compounded tirzepatide and semaglutide stem from a need to offer some patients a form of the medication that does not involve needles or swallowing a pill, a seamless and less intimidating experience with taking medication.

Needle phobia: A significant number of patients experience a deep fear of needles and injections. The sublingual form eliminates this concern, making the administration process less daunting.

Pain-free administration: Unlike injections that can cause discomfort, the sublingual route is pain-free, enhancing the chance for patient compliance and satisfaction.

Easy to titrate: Sublingual forms make tailoring dosage to individual needs simpler and more flexible. This is useful, especially in the initial stages of therapy or when adjustments are needed for optimal efficacy.

Ability to offer a daily sublingual “lower-dose” option after reaching goal weight: Prescribers often discuss what to do when a patient reaches their goal weight. Very low daily dosing has been proposed as an easy way to titrate with lower dosing.

Our specialized sublingual compounding base is called SubMagna™

Not all liquid bases are created equal, especially when it comes to sublingual absorption.

See how our sublingual liquid stands out:

  • Unique permeation-enhancing properties
    • Which facilitates the absorption of high molecular weight drugs like tirzepatide and semaglutide.
  • Optimal contact time of the drug under the tongue
    • SubMagna™ has absorption-enhancing properties that increase the duration of time that the liquid medication remains in contact under the tongue, making the medication delivery more efficient.
  • Easy for patients to use
    • GLP-1 medications (tirzepatide and semaglutide), when compounded in SubMagna™ SL liquid, is dispensed in a manner that ensures ease of use.
  • Small volume dosing
    • The dose is administered in small volumes (no more than 1 ml) under the tongue, with patients advised to avoid swallowing immediately to maximize absorption.
  • Flavoring
    • Plays a key role here, especially since the taste of GLP-1 medications may not be very palatable. Compounding pharmacies can add specific flavors to improve the experience.

The Future of Sublingual Compounded Tirzepatide and Semaglutide (GLP-1 Medications)

As we venture into this new era of medication administration, the potential of sublingual compounded semaglutide, facilitated by bases like SubMagna™ SL, opens up exciting possibilities. Not only does it promise a more patient-friendly option, but it also paves the way for advancements in the delivery of other medications, enhancing the overall healthcare experience.

Q&A with Steve and Viral: GLP-1 Experts

Viral, PharmD from Town & Country Compounding discusses why some patients might prefer Liquid Sublingual Semaglutide & Tirzepatide over injections.

Q: Why might a patient prefer sublingual GLP-1 medications, like semaglutide or tirzepatide, over injections?

A: Fear of needles, needle phobia is a real thing. Some people just can’t do it. The convenience and comfort of a pain-free administration. Easier dose adjustments than with injections or tablets, which have their set strengths and concentrations.

Q: What makes SubMagna™ suitable for sublingual absorption of GLP-1 medications such as semaglutide?

A: Its permeation-enhancing properties; ability to deliver high-molecular-weight drugs efficiently. It ensures increased contact time under the tongue for “more efficient” absorption.

Q: Can any liquid base be used for sublingual semaglutide?

A: No, specialized bases like SubMagna™ are necessary for effective sublingual absorption. Some pharmacies, who may only “dabble” in compounding, may try to put this in any basic sublingual base or even water. It is not advised. High-level compounders have access to this specialized base called SubMagna™ SL.

Q: What are the potential benefits of sublingual administration over traditional methods?

A: It improves patient compliance; offers precise and flexible dosing; convenience; and offers an opportunity for some people to have access to the medication who otherwise may not try it.

Town & Country Compounding Pharmacy is located at
Town & Country Compounding Pharmacy is located at 535 East Crescent Ave Ramsey, NJ 07446

Town & Country Compounding provides the most advanced formulations based on the most recent research and peer-reviewed guidelines.

We work with patients and their medical providers to customize solutions that are right for their individual needs when commercially-made medications are not showing results.

Medication is not one-size-fits-all. 

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