Hypogonadism in men is primarily a state involving lower than expected levels of testosterone, and traditionally this condition has been treated almost exclusively with testosterone supplementation. However, low testosterone can be fairly complex, involving a myriad of factors including the inability of the testes to produce sufficient testosterone, improper brain signaling, and excess estrogen.

In some men, clear reasons behind low testosterone can be difficult to determine. The end result, though, can be the same: insufficient testosterone that results in an unhealthy life and is often characterized by symptoms such as loss of libido, erectile dysfunction, depressed mood, and lethargy. After proper diagnosis, including testing for testosterone, estrogen, and luteinizing hormone (LH), properly directed therapy can be dramatically effective in reversing these symptoms and providing a healthier, more robust lifestyle.