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What is the Appropriate Dosage of Low Dose Naltrexone (LDN)?

T&C Compounding – Experts in the Compounding of LDN


For most patients, a starting titration Rx would be:

Rx: Naltrexone 1.5 mg #63 & Naltrexone 0.5 mg, quantity #42

SIG: Take 1 (1.5 mg capsule) orally daily prior to bedtime, increasing by 0.5 mgweekly (every 7 days) until a dose between 3 mg to 4.5 mg is achieved

Once dose of 3 mg – 4.5 mg/day is achieved, next Rx can be written as:

Rx: Naltrexone __mg capsules, quantity, typically choose #30__ #60__ or #90__ Other__

SIG: Take 1 capsule daily as maintenance therapy

If a lower starting dose is desired, the Rx can be written as:

Rx: Naltrexone 0.5 mg #___ (#100-300 is suggested)

SIG: Take 1 capsule (0.5 mg) daily prior to bedtime and increase each week by 1 capsule (0.5 mg) until an effective dose is reached. (Typically a dose between 3 mg to 4.5 mg)

Once dose of 3 mg – 4.5 mg/day is achieved, next Rx can be written as:

Rx: Naltrexone __mg capsules

SIG: Take one capsule daily as maintenance therapy. (#30, #60, or #90 is typical).

Patients with Hashimoto’s and Graves’ disease: Patients should be monitored for symptoms of fast pulse, palpitations, or sudden onset of insomnia. If any of these occur, thyroid adjustment may be needed.

Contact T&C Compounding and talk to our New Jersey Low Dose Naltrexone (LDN) Experts TODAY!

How T&C Compounding Pharmacists Work with Physicians

Proper Titration

It really does take an experienced pharmacist and experienced physician working together to get to the sweet spot with dosing for the specific condition. It’s not as simple as starting a titration at 1.5mg and then going all the way to 4.5. We have seen situations where the patient gets full pain relief at 3mg and must stop, but if they keep going, they will lose the results.

This is the dosing that most physicians are aware of, however, over the past couple of years, the dosing has been greatly expanded. Many physicians are not aware that when we have patients on chronic opioid therapy we will sometimes start the dose as low as 0.001mg (1mcg) and have witnessed chronic pain patients receive relief on doses as low as 0.002mg (2mcg) daily. We have also seen where someone will titrate up too quickly for their body and miss the positive results. Depending on the disease, we may want to start much lower.  And…when dealing with opioids, it is critical to work with a pharmacy such as T&C Compounding who has experience with titration protocols for both ultra-low dose naltrexone and very low dose naltrexone. T&C Compounding works with some of the most experienced pain physicians out there and we are currently working on partnering with them for various clinical trials; this is very exciting.

Truly Customized for Individual Needs

We have worked with doctors to look at what the patient is on and we help slowly wean off the opioid while starting with either very low dose naltrexone or ultra-low dose naltrexone (microgram dosing). Then, we help slowly add-back LDN into a customized LDN titration and then offer suggestions to complement this therapy depending on the situation. Many practitioners are not aware of these new dosing protocols and Town & Country is able to educate them on these protocols and assist them with their patients.

Do You Need a Referral to a Low Dose Naltrexone (LDN) Prescriber?

T&C Compounding works with the most prestigious providers. We work with you and health providers/specialists to formulate the most customized medication regimens to fit your specific needs. Medication is not one-size-fits-all, our compounding specialists use precise compounding techniques & equipment to get you the best solution.


Low Dose Naltrexone (LDN) FAQ

Frequently Asked Questions

It’s important to ask questions when researching medications, especially when it comes to pain relief. Many individuals looking for alternatives to addictive opioids have found Low Dose Naltrexone (LDN) can be the solution. T&C Compounding’s  John Herr, RPh., has become a national expert by studying and connecting with global experts in LDN, and has helped a vast amount of patients get through chronic pain. Contact T&C to get more info.


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Low Dose Naltrexone (LDN) Success Stories

Finding solutions for chronic pain & autoimmune conditions can be a difficult process. Share your positive experience of Low Dose Naltrexone (LDN) with others that are considering and researching non-opioid options. Hearing real-life results from real patients & providers can give individuals the confidence they need.

T&C Compounding holds regular seminars connecting patients & providers with newest advancements in utilizing LDN for Chronic Pain & Autoimmune Conditions. We are always welcoming patients that have found success to share their stories with the community. We encourage you to share with individuals that may be suffering, so that they may find the relief they are looking for.


Would you like to speak about your positive experience at one of our upcoming LDN Seminars? We’d love to have you!

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Do You Suffer From Chronic Pain?

Low Dose Naltrexone (LDN) has grown as patients' preferred alternative to addictive opioids. 

T&C LDN Experts can help refer you to a prescriber in your area & provide you with more information.

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Ask us any questions you might have about LDN.
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