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Low Dose Naltrexone (LDN)

T&C Compounding – Experts in the Compounding of LDN


Naltrexone belongs to a class of drugs known as opioid antagonists. Naltrexone blocks opiate drugs from binding to the opioid receptors, which can result in increased endorphin and enkephalin release. Therefore, this results in reduced: 1. signaling and release of inflammatory substances, 2. nerve cell inflammation and 3. autoimmune mediators.

Which patients may benefit from LDN therapy?

Listen to LDN Radio Interviews with T&C LDN Experts.

LDN Radio: John Herr, RPh.>>

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• Down regulates inflammatory cytokine release, oncogene expression and auto-immune cascades

• In the Central Nervous System (CNS) it reduces toll-like receptor signaling and glial cell activation resulting in reduced inflammatory cytokines and reduced neuro-inflammation

• In the Peripheral Nervous System (PNS) it modulates T & B lymphocyte production (example: gut inflammation), and reduces inflammatory cytokines (IL6, IL12, TNF alpha) and suppresses tumor growth factor (NF-kB)

When taken at bedtime, the short acting LDN binds to the receptors which leads to a brief blockade of opioid receptors between 2 am and 4 am. This blockade is believed to up-regulate vital elements of the immune system by causing an increase in endorphin and enkephalin production.

John Herr, PCCA Advisory Council, Owner of T&C Compounding Pharmacy


Expert Pharmacist John Herr, RPh has worked with researchers, physicians, and patients worldwide to become an expert in proper titrations & dosage of Low Dose Naltrexone (LDN).

He has observed its multiple treatment benefits for chronic pain & various autoimmune conditions.

Learn More About LDN

Do You Need a Referral to a Low Dose Naltrexone (LDN) Prescriber?

T&C Compounding works with the most prestigious providers. We work with you and health providers/specialists to formulate the most customized medication regimens to fit your specific needs. Medication is not one-size-fits-all, our compounding specialists use precise compounding techniques & equipment to get you the best solution.

Proud Member of the LDN Research Trust

Town & Country Compounding remains dedicated to LDN research. We continue to uphold high standards in providing quality customized medication to our community.

T&C Compounding’s Latest Blogs on Low Dose Naltrexone (LDN)

A Discussion on Our Seminar on Low Dose Naltrexone (LDN) in Autoimmune Conditions & Chronic Pain

A Discussion on Our Seminar on Low Dose Naltrexone (LDN) in Autoimmune Conditions & Chronic Pain

Recently, a seminar about LDN was hosted at Town & Country Compounding in Ramsey, NJ (and via zoom) with LDN expert presenters Dr... Read More →
Improving Female Sexual Arousal and Interest

Improving Female Sexual Arousal and Interest

“No honey, I have a headache.” Remember hearing that jokingly in your younger years? It can become truth and is a common complaint.. Read More →
Addressing Gastrointestinal & Rectal Issues with Low Dose Naltrexone (LDN) & Other Compounded Meds

Addressing Gastrointestinal & Rectal Issues with Low Dose Naltrexone (LDN) & Other Compounded Meds

Painful and bothersome gastrointestinal and rectal issues can negatively affect a person’s quality of life. If you have problems such as hemorrhoids, anal.. Read More →
Expert Health Tips to a Happier and Healthier 2021

Expert Health Tips to a Happier and Healthier 2021

2021 resolutions: Lose weight, control/manage anxiety & depression worsened by COVID. Read on CBD, Naltrexone (LDN), MIC Injections and more... Read More →
LDN: A Possible Option for Lupus and Rheumatoid Arthritis Patients

LDN: A Possible Option for Lupus and Rheumatoid Arthritis Patients

While manufacturers of both raw materials and finished products struggle to ramp up production to meet this unprecedented demand, Town & Country Compounding.. Read More →
Press Release: As COVID-19 Supply Shortages Affect First Responders and Patients, New Jersey Compounders Step In

Press Release: As COVID-19 Supply Shortages Affect First Responders and Patients, New Jersey Compounders Step In

Town and Country Compounding Pharmacy Donated Hand Sanitizer to the Hoboken Police Department. .. Read More →

Low Dose Naltrexone (LDN) FAQ

Frequently Asked Questions

It’s important to ask questions when researching medications, especially when it comes to pain relief. Many individuals looking for alternatives to addictive opioids have found Low Dose Naltrexone (LDN) can be the solution. T&C Compounding’s  John Herr, RPh., has become a national expert by studying and connecting with global experts in LDN, and has helped a vast amount of patients get through chronic pain. Contact T&C to get more info.

Low Dose Naltrexone Dosage Forms

Find the right LDN Dosage Form for your specific needs & preferences.


The titration kit enables a patient to start their low dose naltrexone therapy and slowly ease into the dose that is appropriate for them. Kit determines personal effective dose, or maintenance dose that is right for the patient.



Taking LDN in oral capsules by mouth is the most cost-effective means of administering naltrexone and it’s the one we see most commonly prescribed. The capsules may be compounded lactose free & specific allergens can be avoided upon request. 



Naltrexone in a liquid may be prescribed for patients who may have a hard time swallowing oral capsules or for patients who may have to adjust their dose quite often or who have not yet found their perfect dose. Flavored to preference.



Some medical conditions require the topical administration of naltrexone alone or in combination with other active pharmaceutical ingredients (API’s). LDN is compounded into elegant topical cream bases that are non-irritating for the patient.



Certain medical conditions may require LDN to be administered by itself or in combination with another drug in a vaginal cream or gel.
Vaginal Applicator for LDN administrating with detailed instructions included.


Low Dose Naltrexone (LDN) Success Stories

Finding solutions for chronic pain & autoimmune conditions can be a difficult process. Share your positive experience of Low Dose Naltrexone (LDN) with others that are considering and researching non-opioid options. Hearing real-life results from real patients & providers can give individuals the confidence they need.

T&C Compounding holds regular seminars connecting patients & providers with newest advancements in utilizing LDN for Chronic Pain & Autoimmune Conditions. We are always welcoming patients that have found success to share their stories with the community. We encourage you to share with individuals that may be suffering, so that they may find the relief they are looking for.

Submit Testimonial

Would you like to speak about your positive experience at one of our upcoming LDN Seminars? We’d love to have you!


Featured LDN Review Article: The Use of Low-Dose Naltrexone (LDN)
as a Novel Anti-Inflammatory Treatment for Chronic Pain

Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease,multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells.

This review covers the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.

*Younger, J., Parkitny, L., & Mclain, D. (2014). The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clinical Rheumatology, 33(4), 451-459. doi:10.1007/s10067-014-2517-2

Compounded Low Dose Naltrexone (LDN) Titration Kit

Find the right dosage for YOU. Owner and expert pharmacist John Herr, RPh explains how T&C’s LDN Titration Kit provides you the most ideal dosage strength appropriate to yield the results you desire. We work with you, along with your physician to get the relief you need.

LDN Titration Kit

6 Ways Naltrexone (LDN) Helps with Weight Loss

Dr. Westin Childs is dedicated to helping people with thyroid problems and hormonal imbalances in fining a solution. He is focused on personalized and functional medicine and has practiced in treating Hypothyroidism, Insulin resistance, and Leptin resistance. In this video, Dr. Westin Childs explains 6 ways Naltrexone (LDN) helps with weight loss and who should consider using it.

Tips for Achieving 2020 Weight Loss Goals

Brain (CNS) Inflammation

Recently, NBC News released a fascinating report linking central nervous system inflammation and Alzheimer’s. If true, is the first truly “attackable” angle to help prevent and potentially mitigate the symptoms of Alzheimer’s.

This could hold opportunities to advance and focus medication development towards neuroinflammation.

Low Dose Naltrexone (LDN), may be exceptionally good at reducing neuroinflammation, to the point where it could accomplish symptom reductions for neurological diseases and conditions that aren’t possible with other medications.

Upcoming Informational Seminars

RSVP for our next informational seminar.

Upcoming T&C Webinars