Low Dose Naltrexone (LDN)

Town & Country Compounding – Experts in the Compounding of LDN

Our accreditations place us in the top 1% of compounding pharmacies

For Prescribers

LDN Video From a Pain Management Specialist.

How does Low Dose Naltrexone work?

  • Down regulates inflammatory cytokine release, oncogene expression and auto-immune cascades
  • In the Central Nervous System (CNS) it reduces toll-like receptor signaling and glial cell activation resulting in reduced inflammatory cytokines and reduced neuro-inflammation
  • In the Peripheral Nervous System (PNS) it modulates T & B lymphocyte production (example: gut inflammation), and reduces inflammatory cytokines (IL6, IL12, TNF alpha) and suppresses tumor growth factor (NF-kB)

When taken at bedtime, the short acting LDN binds to the receptors which leads to a brief blockade of opioid receptors between 2 am and 4 am. This blockade is believed to up-regulate vital elements of the immune system by causing an increase in endorphin and enkephalin production.

Low Dose Naltrexone (LDN) Titration Kits

We have a true LDN focused program in which we collaborate with physicians to help their patients achieve positive outcomes and enhance their quality of life.

Titrating the LDN dose is very important for success.

We provide titration kits to help each patient find the perfect dose that works for them.

Video: Learn more about Low Dose Naltrexone (LDN) titration kits from pharmacist John Herr, RPh.

LDN Patient Follow-Up Program

We have developed a patient follow-up program in which patients are contacted via text, email, or phone three weeks after dispensing to check how they are doing with their therapy.

We ask questions that gauge patient response to optimize their therapy success.

Discount with a 60-day supply and 90-day supply.

After the maintenance dose is achieved.

Expert LDN Pharmacists

Our pharmacists are trained explicitly in compounding and have expert knowledge about conditions or illnesses for which patients may use LDN.

“Town & Country Compounding’s LDN titration kits and their commitment to educating patients have helped my success rates in managing pain in patients with autoimmune diseases.”

Dr. Asher Goldstein, MD

Chairman of The Pain Management/Pain & Palliative Medicine Department at Holy Name Medical Center in Hackensack, NJ


Proud Member of the LDN Research Trust

Town & Country Compounding remains dedicated to LDN research. We continue to uphold high standards in providing quality customized medication to our community.

Low Dose Naltrexone Dosage Forms

Find the right LDN dosage form for patients’ specific needs & preferences.

Town & Country Compounding works with the most prestigious providers. We work with you and health providers/specialists to formulate the most customized medication regimens to fit your specific needs.

John Herr, PCCA Advisory Council, Owner of Town & Country Compounding Pharmacy

Low Dose Naltrexone (LDN) expert John Herr, RPh.

Expert Pharmacist John Herr, RPh. has worked with researchers, physicians, and patients worldwide to become an expert in proper titrations & dosage of Low Dose Naltrexone (LDN).

He has observed its multiple benefits for chronic pain & various autoimmune conditions.

Low Dose Naltrexone (LDN) Resources
Featured LDN Review Article: The Use of Low-Dose Naltrexone (LDN) as a Novel Anti-Inflammatory Treatment for Chronic Pain

Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells.

This review covers the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.

*Younger, J., Parkitny, L., & Mclain, D. (2014). The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clinical Rheumatology, 33(4), 451-459. doi:10.1007/s10067-014-2517-2

Dr. Asher Goldstein
Board Certified Physician Specializing in Pain Management and Opioid Detox

Learn About LDN From an Experienced Physician

Get insight from providers that prescribe Low Dose Naltrexone (LDN) for their patients.

Blogs on Low Dose Naltrexone (LDN)

Call or Text: 201-447-2020